In the year 2000, a research consortium led by one scientist — Dr. J. Craig Venter — read the human genome for the first time. It cost three billion dollars and took thirteen years.
Today, the same sequencing can be done for the price of a good suit. What has not changed in twenty-five years is the genome itself. The 6.4 billion base pairs you carry today are the same 6.4 billion base pairs that were written into you at conception, and they will be the same on the day you die. Among them are the instructions that determine — to a degree that surprises most cardiologists — whether and when you will have a heart attack.
Approximately half of your lifetime cardiovascular risk is genetic. Polygenic risk scores derived from hundreds of thousands of sequenced genomes now predict coronary artery disease with greater accuracy than any cholesterol panel ever has. A single inherited variant in the PCSK9 gene can elevate your lifetime risk of heart attack twentyfold. The condition has a name — familial hypercholesterolemia — and it affects approximately one in two hundred and fifty adults. Ninety percent of them do not know they have it.
The annual physical, which measures three cholesterol numbers and a blood pressure reading, is incapable of telling you any of this. It is not designed to. It looks at the present. The genome describes the foundations.
This is what Human Longevity was built to read.
He was fifty-four. He called himself healthy. By every conventional measure, he was. His annual physical had been unremarkable for two decades.
Whole genome sequencing, performed in a single afternoon, identified an autosomal dominant variant in his PCSK9 gene — a clear marker for familial hypercholesterolemia, the same inherited condition that had ended his father’s life and his grandfather’s. A CT coronary calcium score, ordered the following week, confirmed early disease. An advanced lipid panel quantified it. Within a month, his cardiologist had prescribed a twice-yearly siRNA therapy specifically indicated for his variant.
He is now expected to live a normal lifespan.
Identifying details altered. Outcome representative; individual results vary.
Each finding in your report is clinically formatted and physician-ready — designed to be handed to your cardiologist and acted upon.
A single number, calibrated against hundreds of thousands of sequenced genomes, expressing your individual lifetime risk for coronary artery disease and heart attack — the most powerful predictor in cardiology that is not yet on most physicians' order forms.
Complete analysis of PCSK9, LDLR, and APOB — the three principal genes implicated in familial hypercholesterolemia. The condition affects an estimated one in two hundred and fifty adults. Nine in ten do not yet know they carry it.
Long QT syndrome. Hypertrophic cardiomyopathy. Brugada. Catecholaminergic polymorphic ventricular tachycardia. The conditions that, untreated, cause sudden cardiac death in otherwise healthy adults.
How your genes influence your response to statins, anticoagulants, beta-blockers, and over two hundred additional medications — provided so that the right intervention can be prescribed at the right dose, the first time.
Human Longevity was founded in 2013 by the scientist who sequenced the first human genome. Its work has since been published in Nature Genetics, PNAS, and the American Journal of Human Genetics.
Mass General Brigham · Siemens Healthineers · Illumina · Buck Institute
Cleerly · Capital Group · J. Craig Venter Institute · CorTechs.ai · AMRA
Scientific Advisory Board includes Nobel laureates Geoffrey Hinton and Michael Levitt
A clinical-grade whole genome sequencing in a CLIA-certified laboratory, returned as a physician-ready report — and re-analyzed each year as the science advances.
One-time payment. No subscription. Saliva collection at home — no clinic visit, no blood draw. Eligible under HSA and FSA accounts in the United States. Processed in HLI’s CLIA-certified laboratory. Stored in HIPAA-compliant infrastructure. Same sequencing used in the $8,000 Executive Health Assessment.
To begin, request your sequencing kit. The collection is performed at home. The report is delivered to you, and yours to share with the physician of your choosing.
Or speak with a clinical specialist · 844-838-3322 · San Diego & San Francisco