50% of your heart attack risk is hiding in your DNA.
A blood pressure cuff and a cholesterol panel can't see it. Your father's heart attack at 52 won't warn you in time. But a single saliva sample — sequenced once — reveals the genetic risk you've been carrying since birth, and gives your physician a 30-year head start.
One-time. Yours for life. Same clinical-grade WGS used in our$8,000 Executive Health program.
CLIA-certified labFounded by Dr. J. Craig Venter$600M invested in researchHSA / FSA eligible
Clinical-Grade WGS·6.4 Billion Base Pairs·Polygenic Cardiovascular Risk Score·Pharmacogenomics for 200+ Medications·One-Time $599·Lifetime Re-Analysis·Clinical-Grade WGS·6.4 Billion Base Pairs·Polygenic Cardiovascular Risk Score·Pharmacogenomics for 200+ Medications·One-Time $599·Lifetime Re-Analysis·
The Cardiovascular Problem No One Talks About
Heart disease kills 2,068 Americans every day. Most of them had "normal" cholesterol.
Your annual physical measures total cholesterol, LDL, and blood pressure — three numbers. Those three numbers miss the people who carry a genetic variant for familial hypercholesterolemia. They miss elevated Lp(a), the inherited cholesterol particle that drives 1 in 5 heart attacks. They miss the polygenic score that predicts 40–50% of your lifetime cardiac risk before you've ever had a symptom.
Your genome holds all of it. And you only have to sequence it once.
702,880
U.S. deaths per year
Heart disease is the #1 cause of death in America, every year, by a wide margin.
50%
Genetic risk
Approximately half of your lifetime heart attack risk is encoded in your DNA at birth.
1 in 250
Have familial hypercholesterolemia
A single inherited variant that increases heart attack risk by up to 20×. 90% are undiagnosed.
$599
One-time
Sequenced once. Re-analyzed every year as the science advances. Yours for life.
A Real Client · Identifying Information Changed
54-year-old male. Self-described "healthy." Father died at 50. Grandfather died at 50.
He came to Human Longevity for an Executive Health assessment. Within 24 hours, three independent data sources — his genome, his coronary calcium scan, and his blood — all pointed to the same diagnosis his standard physical had missed for decades.
Case File · Cardiovascular Genomics
Genetics, imaging, and blood all pointed to the same condition.
Family history
Father: fatal heart attack at 50. Grandfather: fatal stroke at 50.
Genome finding
PCSK9 autosomal dominant variant — a single gene driving lifetime LDL elevation.
Calcium score
CT coronary calcium of 111 — higher than 90% of men his age.
Bloodwork
Total cholesterol 254 mg/dL. LDL 167 mg/dL.
Diagnosis
Familial hypercholesterolemia. The same condition that killed his father and grandfather.
Treatment
Novartis' siRNA therapy Inclisiran (Leqvio®) — a twice-yearly injection specifically indicated for PCSK9 variants.
The science that found it cost less than $1,000. The standard physical that missed it for 20 years would have, eventually, cost him his life. He's now expected to live a normal lifespan.
Case represents an actual Human Longevity client. Identifying details have been altered for privacy. Individual results vary; this is not a medical claim or guarantee of outcome.
What Most Cardiac Workups Miss
A consumer DNA kit is not a clinical genome. Neither is your annual physical.
Consumer kits analyze less than 0.1% of your DNA. They were designed for ancestry, not cardiology. Here's what they leave on the table — and what clinical-grade whole genome sequencing actually delivers.
Cardiovascular detection capability
Consumer kit
Human Longevity WGS
Genome coverage
< 0.1%
100% · 6.4 billion base pairs
Familial hypercholesterolemia variants
Partial · ancestry-focused
Complete PCSK9, LDLR, APOB analysis
Lp(a) genetic prediction
Not reported
Full polygenic interpretation
Cardiovascular polygenic risk score
Not available
HLI proprietary algorithm
Hereditary arrhythmia genes (Long QT, etc.)
Not analyzed
Full panel
Statin / antiplatelet pharmacogenomics
Limited
200+ medications
Physician-ready clinical report
Consumer summary only
Yes — share with your cardiologist
Annual re-analysis as science advances
No
Included for life
What's In Your Report
Six cardiovascular insights you can hand to your cardiologist on Monday.
01
Polygenic Cardiovascular Risk Score
Your individual lifetime risk for coronary artery disease and heart attack, calibrated against hundreds of thousands of sequenced genomes. The single most powerful predictor available today.
02
Familial Hypercholesterolemia Screening
Complete analysis of PCSK9, LDLR, and APOB — the three genes that cause inherited high cholesterol. 1 in 250 people carry a pathogenic variant. 90% don't know it.
03
Hereditary Arrhythmia & Cardiomyopathy Panel
Long QT syndrome, hypertrophic cardiomyopathy, Brugada syndrome, and other inherited rhythm disorders — the conditions that cause sudden cardiac death in apparently healthy adults.
04
Lp(a) Genetic Prediction
Lp(a) is responsible for an estimated 20% of heart attacks and is almost entirely genetically determined. Most doctors have never tested for it. We tell you whether you carry the risk.
05
Cardiovascular Pharmacogenomics
How your genes affect statins, anticoagulants, beta-blockers, and 200+ other medications. Helps your cardiologist choose the right drug at the right dose the first time.
06
Lifetime Re-Analysis
Your genome never changes. The science does. Every year, we re-run your data through the latest published algorithms — and update your report with any new clinically actionable findings, free.
Four Steps · 4–6 Weeks
From your kit to your cardiologist's office.
STEP 01
Order Online
Saliva collection kit ships in 2 business days. $599 one-time. HSA/FSA accepted.
STEP 02
Collect at Home
A simple saliva sample. No blood draw. No clinic visit. Mail it back in the prepaid envelope.
STEP 03
Clinical Analysis
Processed in our CLIA-certified lab. 30× sequencing coverage. AI-interpreted against the largest private genomic database in the world.
STEP 04
Receive Your Report
A clinically formatted PDF in 4–6 weeks. Ready to share with your cardiologist or primary care physician.
From Dr. Wei-Wu He, Executive Chairman
"We are no longer just treating disease. We are predicting and preventing it before it ever begins. This is the true future of medicine.
Dr. Wei-Wu He, PhD · Executive Chairman, Human Longevity · Cloned the original PSA gene · Founding scientist of Human Genome Sciences
Questions, Answered
Everything you'd ask if a friend told you about this at dinner.
Executive Health is a full-day clinical experience: whole-body MRI, cardiac imaging, 120+ biomarkers, physician review, and the genome. The $599 program is the genome alone, returned as a clinical report — same lab, same coverage, same AI interpretation. We made it standalone because the genome is the foundation of every other prevention decision, and most people will never spend $8,000 on a single day of healthcare.
Consumer tests sequence less than 0.1% of your DNA using a genotyping chip — they look at a few specific spots, not the whole book. Many cardiovascular variants (including the one in our case study above) sit outside what consumer kits read. Whole genome sequencing reads all 6.4 billion base pairs, at clinical-grade 30× coverage, in a CLIA-certified lab. It is the difference between a flashlight and stadium floodlights.
Your report is physician-ready — designed to be handed to your cardiologist or primary care doctor for follow-up. For Human Longevity Executive Health members, our clinical team handles the next step directly. For Genomics-only clients, we provide your data and a clinical summary; treatment decisions and prescriptions remain with your physician.
Most private insurers do not currently cover proactive (asymptomatic) whole genome sequencing. However, the cost is eligible under HSA and FSA accounts in the U.S., which makes it pre-tax for most people. We provide the necessary documentation at checkout.
Yes. Your data is stored in HLI's HIPAA-compliant infrastructure, encrypted at rest and in transit. We never sell genomic data to third parties. You can request export or deletion at any time.
An advanced lipid panel measures today's blood. The genome reads the instructions that have been writing your blood chemistry since the day you were conceived. Both matter. The genome tells you which advanced markers to track for the rest of your life — and which interventions are most likely to work for your specific biology.
Human Longevity was founded in 2013 by Dr. J. Craig Venter — the scientist who led the first sequencing of the human genome in 2000. The company has invested over $600 million across a decade building the algorithms used in this report. Our scientific advisory board includes Nobel Laureates Geoffrey Hinton (AI) and Michael Levitt (computational biology).
One More Thing
In the last 24 years, the cost of sequencing a human genome has fallen from $3 billion to under $1,000. The science is no longer the barrier. The bottleneck now is interpretation — translating 6.4 billion base pairs into a finding your cardiologist can act on Monday morning.
That is what HLI spent $600 million building. And it's what your $599 unlocks.
— The Human Longevity Clinical Team
One-Time · Yours For Life
Read your genome. Know your cardiac risk. Act before symptoms.
Same clinical-grade whole genome sequencing used in our $8,000 Executive Health program. $599, one-time. HSA / FSA eligible. CLIA-certified lab.