Education
Member Portal
Get Started
New Research · Farah et al., JACC 2026

40–50% of your
heart attack risk
is in your genome.

A landmark study of 215,695 people proves it. Your cholesterol panel alone can't see it. But a single genome test — read once — predicts your lifetime heart attack risk more accurately than any traditional methodology.

Anatomical heart visualization
50%
Genetic Risk
Source: Farah W. et al., JACC 2026
Around 1 million Americans have a heart attack each year·50% of risk is genetic·Standard tests miss it·HLI algorithm catches 61% more·Whole Genome Sequencing·$599 · HSA/FSA eligible·Around 1 million Americans have a heart attack each year·50% of risk is genetic·Standard tests miss it·HLI algorithm catches 61% more·Whole Genome Sequencing·$599 · HSA/FSA eligible·
The Scale of the Problem

Every year, around 1 million Americans have a heart attack. Most of them didn't see it coming.

They had checkups. They knew their cholesterol. Some even had “good” numbers. What they didn't know — what no standard test measured — was the genetic blueprint already shaping their risk since birth.

The science is clear. The tools now exist. The question is whether you choose to look.

0M+
Americans have a heart attack each year
Heart disease is the #1 cause of death in America.
40–50%
of lifetime risk is written in your DNA
Proven across 215,695 people. Independent of cholesterol and blood pressure.
0%
of high-risk people never identified by standard care
Familial hypercholesterolemia: 1 in 250 Americans carry it. Nine out of ten have never been told.
Person looking upward, hopeful

"She had a normal physical every year. Normal cholesterol. The heart attack came at 47."

Her genome would have flagged it at 35.

Why Your Annual Physical Isn't Enough

Standard tests measure what disease has already done. Your genome measures what it will do.

Blood pressure, cholesterol, and an EKG measure the consequences of years of biological processes already underway. They're essential — but they're looking at the past. Your genome is the blueprint. It tells you what's coming.

CAD Genetic Risk Score
Predicts lifetime susceptibility — strongest ages 40–49, before symptoms appear
Inherited LDL (FH)
Single gene variants that triple lifetime cholesterol exposure — invisible to lipid panels
Inflammatory Pathway
Genetic variants driving chronic inflammation standard CRP tests don't predict
Lp(a) Risk
Causes 1 in 5 heart attacks. Almost entirely genetic. Rarely tested. Highly actionable.
From the research: In a study of 215,695 UK Biobank participants followed for 12 years, genetic factors (CAD PRS) contributed 48.2% of all early-onset coronary risk — independent of cholesterol and blood pressure. Farah et al., JACC 2026.
The Human Longevity Difference

Our algorithm catches 61% more heart attacks before they happen.

Built on research published in the Journal of the American College of Cardiology, Human Longevity's 4-biomarker algorithm — combining your genetic risk score with lipid and inflammation markers — dramatically outperforms standard care at identifying who needs intervention now.

Standard Care (PCE alone)
1,445
CAD events prevented per 100,000 screened adults
+61%
more lives
→
Human Longevity 4-Biomarker Model
2,339
CAD events prevented per 100,000 screened adults
The 4 Biomarkers That Change Everything
CAD PRS
1.79× hazard ratio
Your inherited genetic risk score — the strongest single predictor of lifetime CAD
LDL-C
1.60× hazard ratio
Elevated "bad" cholesterol, especially dangerous when genetically driven
hsCRP
1.64× hazard ratio
Inflammatory marker that predicts plaque instability and rupture risk
Lp(a)
1.20× hazard ratio
Inherited particle responsible for 1 in 5 heart attacks

Farah W. et al., "The Biological Blueprint of Coronary Risk." Journal of the American College of Cardiology (JACC), 2026. UK Biobank, N=215,695, 12-year follow-up. Hazard ratios adjusted for age, sex, and traditional risk factors.

The Window of Opportunity

The research shows the best time to test is your 40s. Most people wait until it's too late.

In the JACC study, the 4-biomarker algorithm was most powerful in patients aged 40–49 — because biological risk accumulates decades before any symptom appears. The genome was always there, but the window to act early is closing.

13.8×
Ages 40–49
Risk increase with all 4 markers elevated
4.2×
Ages 50–59
Risk increase with all 4 markers elevated
2.6×
Ages 60–69
Risk increase with all 4 markers elevated
Bottom line: A 40-year-old who discovers elevated CAD PRS + high LDL-C faces a 13.8× higher risk — and has 20 years to aggressively reduce it before symptoms ever appear.
Healthy mature couple
What You'll Know After Your Test

Six things about your heart no blood panel has ever shown you.

One saliva sample. Sequenced once in a CLIA-certified lab at 30× clinical coverage. Returns a physician-ready report your cardiologist can act on.

01

Your Coronary Artery Disease Polygenic Risk Score

Most Important

Your individual lifetime genetic risk for heart attack — calibrated against data from hundreds of thousands of sequenced genomes. The single most powerful predictor of cardiac risk available today. Standard care never measures it.

02

Familial Hypercholesterolemia (FH) Screening

Variants in PCSK9, LDLR, and APOB — the three genes that cause inherited high cholesterol regardless of diet or exercise. 1 in 250 people carry one. 90% have never been told.

03

Lp(a) Genetic Prediction

Lipoprotein(a) drives 1 in 5 heart attacks and is almost entirely written in your DNA. It does not respond to statins. Most cardiologists have never tested for it. Knowing unlocks emerging RNA-interference therapies.

04

Hereditary Arrhythmia & Cardiomyopathy Panel

Long QT syndrome, hypertrophic cardiomyopathy, Brugada syndrome — inherited conditions that cause sudden cardiac death in people with no prior symptoms.

05

Cardiovascular Pharmacogenomics

Your genes determine how you metabolize statins, anticoagulants, and beta-blockers. Knowing this helps your physician prescribe the right drug, at the right dose, on the first try.

06

Lifetime Re-Analysis — Free, Every Year

Your genome doesn't change. The science does. Every year, we re-run your data through the latest published algorithms and update your report with any new clinically actionable findings. At no additional cost. Ever.

How It Works

From your kitchen to your cardiologist. In 4 steps.

No clinic visit required. Kit ships to your door in 2 business days. HSA and FSA eligible.

01

Order Online

Kit ships in 2 business days. $599, one-time. HSA/FSA accepted. No clinic visit required.

02

Spit in a Tube

A simple saliva collection. Takes 5 minutes at home. Mail it back in the prepaid envelope.

03

Clinical-Grade Sequencing

Processed in a CLIA-certified lab. 30× whole genome coverage. AI-analyzed against the largest private genomic database in the world.

04

Your Report

Clinician-formatted PDF in 4–6 weeks. Physician-ready. Share directly with your cardiologist or primary care physician.

HLI Physician
"We are no longer just treating disease. We are predicting and preventing it — before it ever begins. The genome is where that story starts."
Dr. Wei-Wu He, PhD
Executive Chairman, Human Longevity, Inc. · Cloned the original PSA gene · Founding scientist, Human Genome Sciences
Your Questions

What people ask before ordering.

Questions from real patients who've taken the test or are considering it.

Consumer kits scan less than 0.1% of your DNA using a genotyping chip — they look at a few hundred thousand fixed spots. Whole genome sequencing reads all 6.4 billion base pairs. Many cardiovascular variants, including familial hypercholesterolemia mutations and the full CAD polygenic risk score, sit outside what consumer kits ever look at. It's the difference between reading a chapter and reading the entire book.
Yes — and this is exactly the point. The JACC study found that 48% of early-onset coronary risk is driven by genetics, independent of cholesterol. People with completely normal lipid panels still carry CAD polygenic risk scores that triple their lifetime heart attack probability. Lp(a) — responsible for 1 in 5 heart attacks — is almost invisible to a standard lipid panel but fully visible in your genome.
Your report is designed to hand to your physician. We provide a clinician-formatted PDF with actionable findings, thresholds, and relevant literature references. For Executive Health members, our clinical team handles follow-up directly. For Genomics-only clients, we provide the data — treatment decisions remain with your licensed physician.
No. You sequence your genome once. It doesn't change. The $599 covers sequencing, your initial report, and lifetime re-analysis as the science advances. We re-run your data against new published algorithms every year and update your report with any newly discovered actionable findings — at no additional cost.
In a hypothetical cohort of 100,000 borderline-risk adults, adding the 4-biomarker genomic model to standard care (PCE) increased targeted statin eligibility by 32.3% (Net Reclassification Index). Translating that into events: standard care prevented 1,445 CAD events; the biological model prevented 2,339 — a 61% improvement. This is from Farah et al., JACC 2026, based on real outcomes across 215,695 UK Biobank participants followed for 12 years.
Human Longevity was founded in 2013 by Dr. J. Craig Venter — the scientist who led the first sequencing of the human genome. The company has invested over $600 million building genomic databases and algorithms over a decade. Our scientific advisory board includes Nobel Laureates Geoffrey Hinton (AI) and Michael Levitt (computational biology).
One Test. A Lifetime of Knowing.

Stop guessing about your heart.

Around 1 million Americans will have a heart attack this year. Half are carrying genetic risk their doctors have never seen. For $599 — one-time, HSA/FSA eligible — you can see yours.

Primary Citation: Farah, R. et al. Combining genomics with lipid and inflammatory biomarkers to predict coronary artery disease risk: UK Biobank study. J. Am. Coll. Cardiol. 87, 2785–2803 (2026). UK Biobank, N=215,695, 12-year follow-up. · This page is for educational purposes. Individual results vary. Heart attack risk prediction and prevention requires evaluation by a licensed clinician. Human Longevity, Inc. is not the author of the referenced study.