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Book cover: 7 Reasons You Can't Afford Not to Sequence Your Genome — Your DNA. Your Future. The Power of Knowing. By Wei-Wu He, PhD.
Human Longevity — Whole Genome Sequencing

Seven reasons the most important medical decision of your life now costs $599.

For most of human history, your genome was invisible. It shaped your risk of heart disease, cancer, dementia, diabetes, and drug response — but you couldn’t see it, measure it, or use it to guide prevention. That has changed.

At Human Longevity, a clinical-grade whole genome sequence is now $599 — with AI-powered interpretation to help you and your physician understand what your genome means for your lifetime health.

By Wei-Wu He, PhD
Chairman and CEO, Human Longevity, Inc.
One of the great medical opportunities of our time

More than two decades ago, decoding the first human genome took years of work and billions of dollars. Today, a clinical-grade whole genome sequence is available for $599 — one of the most important medical opportunities of our time.

$3B → $599
First genome cost, versus today
6.4B
Base pairs in your genome — fully sequenced
300,000
Years humans had no way to read their own code
The 7 reasons

Why you can’t afford not to sequence your genome.

Reason1

Whole genome sequencing used to be impossible for most people. Now it’s $599.

For decades, whole genome sequencing was confined to research institutions and the wealthy. Today, a clinical-grade WGS is $599 — the same complete analysis once reserved for HLI’s executive health program.

This is not a consumer ancestry test, and it is not a small panel. It is a clinical-grade reading of all 6.4 billion base pairs of your DNA, AI-interpreted for disease risks, drug-response risks, and prevention.

Your genome doesn’t change — sequencing it once creates a lifelong health asset. But the science changes daily, which is why interpretation matters as much as sequencing.

Reason2

The biggest killers of our time are deeply connected to your genome.

Cardiovascular disease, cancer, dementia, and diabetes develop silently for years before they become visible. Your genome can reveal inherited risk long before any symptom appears.

A 2026 JACC study using UK Biobank data combined a coronary artery disease polygenic risk score with LDL, Lp(a), and hsCRP to meaningfully improve prediction — a glimpse of where prevention is headed.

The future of medicine is identifying risk early enough to act on it. Your genome is the starting point.

Reason3

Your genome can help determine which drugs are right for you.

Medicine is still too often trial and error. Pharmacogenomics explains why two people can respond completely differently to the same drug and dose.

A 2026 Nature study of 27,885 people found that GLP1R variation was linked to differences in GLP-1 weight-loss response, while GLP1R and GIPR variants were associated with nausea and vomiting. For statins, CPIC guidelines flag SLCO1B1, ABCG2, and CYP2C9.

The goal isn’t to replace your doctor — it’s to give your doctor better information.

Reason4

Many people carry hidden disease-risk variants — and most don’t know it.

You may feel healthy, with normal labs and a reassuring family history, and still carry silent, actionable risk. Population studies (All of Us / Communications Biology) found pathogenic and likely-pathogenic variants in actionable genes across every ancestry group — including hereditary breast and ovarian cancer and familial hypercholesterolemia.

Angelina Jolie raised global awareness of BRCA1. The same principle applies to colon, prostate, and pancreatic cancer, and to heart disease.

Don’t ignore silent risks just because they’re silent. Knowing is the only way to act.

Reason5

Your genome isn’t just about you. It’s about your family.

When you sequence your genome, you may learn something important for your children, siblings, parents, and extended family.

In 2025, Johns Hopkins reported a recurrent MMS22L F722fs mutation tied to higher prostate cancer risk in Ashkenazi Jewish men. HLI searched its database and identified seven carrier families within a single day — including women whose male relatives may carry the same risk.

One person’s genome can become a warning system for an entire family.

Reason6

Static reports aren’t enough. You need a dynamic, AI-powered genomic interpreter.

Sequencing is only the beginning. The real question is who keeps interpreting your genome as science advances. New papers, disease genes, drug-response variants, and risk models emerge every week.

A printed report goes stale the moment it’s printed. A dynamic AI platform keeps learning. In the MMS22L example, the time from publication to identifying relevant families was under a day.

The future isn’t just sequencing — it’s continuous interpretation.

Reason7

The process is simple — and the opportunity is historic.

Sign up, and a saliva kit arrives at your home. Collect your sample in a few minutes, mail it back, and your report appears in the HLI app within a few weeks — becoming part of a lifelong, AI-powered prevention platform.

Homo sapiens existed for roughly 300,000 years with no way to read this code. In 2001, we decoded the first genome at enormous cost. Today it’s $599.

That’s not just a price drop. It’s a medical revolution.

How it works
1

Sign up

Complete a simple online order for $599. No clinic visit, no blood draw required.

2

Kit at home

A saliva collection kit arrives at your door. Collect your sample in a few minutes.

3

Mail it back

Send your sample to HLI’s CLIA-certified lab using the prepaid return packaging.

4

Report in the app

Within a few weeks your report appears in the HLI app — a lifelong prevention platform.

The goal is prevention

Know early.
Live longer.

Your genome is the foundation. AI is the interpreter. Prevention is the goal.

Many cancers — including breast and prostate — are far more treatable when found early. A Stage I diagnosis can often be treated with curative intent, while Stage IV is far harder. Knowing your genomic risk is how you give yourself the earliest possible start.

One-time investment
$599
Clinical-grade WGS. AI-interpreted. A lifelong asset.
All 6.4 billion base pairs, fully sequenced
AI-powered, continuously updated interpretation
Inherited risk for the biggest killers
Pharmacogenomics for drug-response risk
Insights that can protect your whole family
A simple at-home saliva kit
References

Claims on this page are drawn from peer-reviewed and clinical sources, including: Journal of the American College of Cardiology (JACC, 2026); Nature (2026); CPIC pharmacogenomic guidelines; Communications Biology (All of Us); European Urology Focus (2025); and reporting in The New York Times. This page is for educational purposes and is not medical advice. Discuss your results with a qualified physician.

Human Longevity, Inc.
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