Genetics

A Deeper Dive into Genomics

Following your visit to the Health Nucleus, our team of clinicians, scientists and bioinformaticians will partner to develop an integrated health report specifically tailored to you utilizing your clinical history and incorporating the data generated from your visit, including your whole genome sequence.

The Health Nucleus Whole Genome report will include medically significant results, as well as other non-clinical information such as traits and ancestry. The Whole Genome report provides insights on your genetic risk for certain illnesses or diseases.

Clinical Insights

The Health Nucleus Whole Genome Reports looks at all known disease associated genes, including:

CMG 59

This consists of a list of 59 important genes as defined by the American College of Medical Genetics and Genomics (ACMG). If mutations are found in these genes, they should be reported to individuals because of their potential high medical importance and actionability.

Disease risks

Identifies medically actionable genetic variants associated with significant current or future health risks across 70 complex diseases:

  • Cancer
  • Neurological
  • Cardiovascular and Metabolic
  • Immunologic, Renal, Respiratory, Hematologic and Rheumatologic

Pharmacogenomics

Helps to predict your responses to 40+ medications, including differences in drug effectiveness and side effects.

Carrier screening

If you are planning a family, understand if you are a carrier of 242+ inherited conditions.

Health Traits/Risks

Provide you with your genetic risk assessment to understand if your DNA has variants that can increase or decrease your risk for different health conditions including the following:

  • Human Leukocyte Antigen (HLA) Type – association with disease risk.
  • Bone health (e.g. Bone mineral density, osteoarthritis)
  • Cancer – inherited gene risk of known cancer-related genes (e.g. bladder, colorectal, esophageal, lung, melanoma, pancreatic, thyroid).
  • Cardiovascular health (e.g. Hypertension, Coronary artery disease [CAD], stroke, atrial fibrillation)
  • Connective tissue conditions (Achilles tendinopathy)
  • Food intolerance and allergy (e.g. Lactose intolerance, celiac, allergies [peanut, shellfish, eggs, milk, etc.])
  • Infectious disease (e.g. Viral resistance)
  • Inflammatory and autoimmune disorders (e.g. Eczema, Rheumatoid arthritis, Systemic sclerosis, Inflammatory bowel disease [IBD])
  • Men’s health (e.g. Prostate cancer)
  • Mental health (e.g. Bipolar disorder, Major depressive disorder, Schizophrenia, Opioid addiction, risk seeking behavior, smoking behavior)
  • Metabolic health (e.g. Thyroid-stimulating hormone level, Type 2 diabetes, lipid levels, Alcohol flush, caffeine, gout, insulin insensitivity, caffeine metabolism, vitamin deficiencies)
  • Neurological (e.g. Alzheimer’s, Parkinson, Multiple sclerosis)
  • Respiratory (e.g. Asthma, COPD)
  • Sensory health (e.g. Exfoliation glaucoma, bitter taste perception, myopia, age-related macular degeneration)”
  • Women’s health (e.g. Breast cancer)

Personal Insights

Variant list

Provides overview of all genetic variants that make you unique and any associated public information.

Ancestry

Learn about your family history and composition (Ancestral composition, maternal and paternal and Neanderthal)

Lifestyle traits

learn about some of the genes thought to be associated with addictive behavior, taste perception, endurance potential, laser eye surgery risk etc.

Traits and physical predictions

Predictions of personal traits including height, weight, eye color and skin color.