Human Genomics

HLI is building the world’s largest human genome sequencing center in the world. Along with computing advances, DNA sequencing has seen an explosion of next generation technologies that are enabling faster and better sequencing of human genomes.

HLI has initially purchased two Illumina HiSeq X Ten Sequencing Systems (with the option for an additional three systems). These next generation sequencing machines are clusters of 10 instruments that provide HLI with an annual throughput of tens of thousands of human genomes. HLI plans to sequence up to 40,000 human genomes per year, with plans to rapidly scale to 100,000 human genomes.

The Human Genome

J. Craig Venter and his teams completed the first draft human genome sequence in 2001, and then went on to complete the first diploid human genome in 2007.


 

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Largest Human Gene-Phenotype Database in the World

We are constructing this robust sequencing operation to compile the most comprehensive and complete human genotype, microbiome, and phenotype database available. This will be obtained by leveraging state-of-the-field and beyond state-of-the-field, next generation assays. A key focus of HLI’s scientific activities will be the identification of biologically relevant patterns in the data. Teams are developing and applying novel statistical genetic, bioinformatics, and data mining algorithms to identify these patterns, these will be implemented on novel computing architectures in partnership with leading computing vendors and centers such as the San Diego Supercomputer Center.